穴位埋线及中药复方对糖尿病大鼠血管内皮功能及胰岛素敏感性的影响

Effects of acupoint catgut embedding therapy and complex prescription in TCM on blood vessel endothelial function and insulin sensitivity in diabetic rats

目的:通过研究穴位埋线及中药复方对糖尿病血管内皮功能和胰岛素敏感性的影响,探讨其防治糖尿病微血管病变(DMAP)的机制。方法:腹腔注射四氧嘧啶建立糖尿病模型,经治疗16周后,测定血浆内皮素(ET)、血清一氧化氮(NO)、尿微量白蛋白(UAE)和胰岛素敏感指数(ISI)等指标。结果:模型组大鼠较正常对照组血浆ET、UAE含量升高,ISI、血清NO降低;经治疗后,ET、UAE明显降低,ISI、NO明显改善(P<0.01或P<0.001)。结论:穴位埋线及中药复方可通过改善血管内皮细胞功能,增强胰岛素敏感性,降低血糖,能有效地防治DMAP。

Objective： To approach the mechanisms of prevention and treatment of diabetic microangiopathy （DMAP） by observing the effect of acupoint catgut embedding therapy （ACET） and complex prescription in TCM （CPTCM） on blood vessel endothelial function and insulin sensitivity （ISI）. Methods： To establish model rats by abdominal cavity injecting alloxan. After being treated respectively with ACET, CPTCM for 16 weeks, plasma endothelins（ET）, serum nitric oxide（NO）, urinary albumin excretion （UAE）, ISI were detected. Resuhs： Compared with normal control group, the content of ET and UAE in model group increased, but ISI and NO decreased remarkably. After being treated, ET and UAE decreased remarkably, NO and ISI increased notably（ P 〈 0.01, P 〈 0.001）. Conclusion： ACET and CPTCM can prevent and treat DMAP effectively by ameliorating the vessel endothelial function, reinforcing insulin sensitivity and decreasing high glucose.