乳腺癌超声征象与ER、PR、C-erbB-2表达的相关性研究

Correlation of color Doppler ultrasound morphologic features with the expression of ER,PR and C-erbB-2 in breast carcinoma

目的初步探讨乳腺癌超声特征与免疫组织化学因子ER、PR及C-erbB-2表达的相关性,为临床乳腺癌术前辅助治疗及预后判断提供更多的信息和科学依据。方法44例乳腺癌均经病理组织学证实,且所有病例在治疗前均行乳腺超声检查,术后测定ER、PR、C-erbB-2的表达。分析乳腺癌的超声表现与三因子表达的相关性。结果①乳腺癌三因子的表达与肿块直径无关(P>0.05)。②有毛刺征的肿块比边缘光整的肿块有更高的ER阳性表达(P<0.01)。③腋窝淋巴结转移组中C-erBb-2阳性表达率高(P<0.05),ER阳性表达率低(P<0.01)。④彩色多普勒显示血流越丰富,C-erBb-2阳性表达率越高(P<0.01)。结论乳腺癌的超声表现与免疫组织化学因子之间有一定的相关性。有毛刺征及无淋巴结转移的乳腺癌有更高的ER阳性表达率,更适合内分泌治疗;血流丰富、有淋巴结转移者C-erBb-2阳性表达率高,预示肿块恶性程度高,预后不良。

Objective To preliminarily study the correlation between manifestations of breast carcinoma on the color Doppler ultrasound and the expression of immunohistochemical factors ER, PR, C-erbB-2, and to provide more information and scientific evidence for the preoperative adjuvant therapy and for the evaluation of the prognosis. Methods Forty-four patients with breast carcinoma on firmed by histopathology were involved in this study. The color Doppler ultrasound was performed in every case before therapy, and ER, PR, C-erbB-2 were performed after operation. The correlation of the color Doppler ultrasonographic manifestations of breast carcinoma and the expressions of the three factors were analyzed. Results （1）There was not a correlation between the size of breast carcinoma and the expression of ER, PR, C-erbB-2 respectively （P〉0.05）. （2）The positive expression rate of ER in spiculated breast carcinoma was higher than non-spiculated （P〈0.01）. （3）The positive expression rate of C-erbB-2 was higher in patients with axillary lymph nodes metastasis （P〈0.05）, the positive expression rate of ER was lower （P〈0. 01）. （4）The positive expression rate of C-erbB-2 was higher in breast carcinoma tissue of plentiful blood stream than lacking of blood stream （P〈0.01）. Conclusion The manifestations of breast carcinoma on the ultrasound have some kind of correlation with expressions of immunohitochemical factors. The breast carcinoma with spiculated and axillary lymph nodes nonmetastasis are less malignant and more suitable for endocrine therapy; the breast carcinoma with plentiful blood flow and axillary lymph nodes metastasis have more possibility about the positive expression of C-erbB-2, indicating more malignant and prognosis badness.