胰腺癌生物治疗的新靶点:MUC1
摘要
胰腺癌预后很差,消耗着巨大的社会卫生资源。目前对胰腺癌的治疗仍缺乏有效的治疗手段。65%胰腺癌病人在诊断明确后半年内死亡,约90%的病人一年内死亡。探索新的有效的治疗方法,是目前急需解决的重要课题。生物治疗,尤其是肿瘤疫苗,作为具有临床应用潜力和价值的治疗手段,近年来开始得到了深入的研究。其关键是选择有效的治疗靶点,即寻找合适的肿瘤相关抗原(tumor associate antigen,TAA)。
出处
《中华肝胆外科杂志》
CAS
CSCD
2007年第12期862-864,共3页
Chinese Journal of Hepatobiliary Surgery
参考文献25
-
1Freelove R, Walling AD. Pancreatic cancer: diagnosis and management. Am Fam Physician, 2006, 73: 485-492.
-
2Zalatnai A. Pancreatic cancer-a continuing challenge in oncology. Pathol Oncol Res, 2003, 4: 252-263.
-
3Rosenberg L, Lipsett M. Biotherapeutic approaches to pancreatic cancer. Expert Opin Biol Ther, 2003, 3:319-337.
-
4Burke PA, Gregg JP, Bakhtiar B, et al. Characterization of MUC1 glycoprotein on prostate cancer for selection of targeting molecules. Int J Oncol, 2006, 29:49-55.
-
5Rajabi-Memari H, Jalali-Javaran M, Rasaee MJ, et al. Expression and characterization of a recombinant single-domain monoclonal antibody against MUC1 mucin in tobacco plants. Hybridoma (Larchmt), 2006, 25 : 209-215.
-
6Dwyer RM, Bergert ER, O'Connor MK, et al. Adenovirus-mediated and targeted expression of the sodium iodide symporter permits in vivo radioiodide imaging and therapy of pancreatictumors. Hum Gene Ther, 2006, 17:661-668.
-
7Schmitz-Winnenthal FH, Volk C, Z'graggen K, et al. High frequencies of functional tumor-reactive T cells in bone mar row and blood of pancreatic cancer patients. Cancer Res, 2005, 65:10079-10087.
-
8Lan MS, Batra SK, Qi WN, et al. Cloning and sequencing of a human pancreatic tumor mucin cDNA. J Biol Chem, 1990, 265: 15294-15299.
-
9Apostolopoulos V, McKenzie FC. Cellular mucins: Targets for immunotherapy. Crit Rev Immunol, 1994,14 : 293.
-
10Price MR, Rye PD, Petrakou E, et al. Summary report on the ISOBM TD-4 Workshop: analysis of 56 monoclonal antibodies against the MUC1 mucin. Tumour Biol, 1998, 19:1-20.
二级参考文献30
-
1Yeo CJ. Pancreatic cancer- 1998 Update.J Am Coil Surg, 1998, 187:429-442.
-
2Rosenberg L, Lipsett M. Biotherapeutic approaches to pancreatic cancer. Expert Opin Biol Ther, 2003, 3 : 319-337.
-
3Goydos JS, Elder E, Whiteside TL, et al. A phase I trial of a synthetic mucin peptide vaccine. Induction of specific immune reactivity in patients with adenocarcinoma. J Surg Res, 1996, 63 : 298-304.
-
4Apostolopoulos V, Pieterz GA, Xing PX, et al. The immunogenicity of MUC1 peptides and fusion protein. Cancer Lett, 1995, 90:21-26.
-
5Brossart P, Heinrich KS, Stuhler G, et al. Identification of HLA-A2-restricted T-cell epitopes derived from the MUC1 tumor antigen for broadly applicable vaccine therapies. Blood, 1999, 93:4309-4317.
-
6Brossart P,Heinrich KS,Stuhler G,et al.Identification of HLA-A2-restricted T-cell epitopes derived from the MUC1 tumor antigen for broadly applicable vaccine therapies.Blood,1999,93:4309-4317.
-
7Johnen H,Kulbe H,Pecher G.Long-term tumor growth suppression in mice immunized with naked DNA of the human tumor antigen mucin (MUC1).Cancer Immunol Immunother,2001,50:356-360.
-
8Roden MM,Lee KH,Panelli MC,et al.A novel cytolysis assay using fluorescent labeling and quantitative fluorescent scanning technology.J Immunol Methods,1999,226:29-41.
-
9Yeo CJ.Pancreatic cancer-1998 Update.J Am Coll Surg,1998,187:429-442.
-
10Rosenberg L,Lipsett M.Biotherapeutic approaches to pancreatic cancer Expert Opin Biol Ther,2003,3:319-337.
共引文献19
-
1白静,孙效,欧伦,刘秀文,汤仲明,宋海峰.重组热激蛋白65-黏蛋白1融合蛋白疫苗的临床前药代动力学(英文)[J].中国药理学与毒理学杂志,2010,24(3):168-173.
-
2袁时芳,李开宗,王岭,颜真,韩苇,张英起.GM-CSF对MUC1基因疫苗抑制乳腺癌生长的增强作用[J].细胞与分子免疫学杂志,2004,20(6):737-740. 被引量:7
-
3白静 ,宋海峰 .乳腺癌治疗性疫苗的研究进展[J].国外医学(免疫学分册),2005,28(4):213-216. 被引量:1
-
4Shi-Fang Yuan,Kai-Zong Li,Ling Wang,Ke-Feng Dou,Zhen Yan,Wei Han,Ying-Qi Zhang.Expression of MUC1 and its significance in hepatocellular and cholangiocarcinoma tissue[J].World Journal of Gastroenterology,2005,11(30):4661-4666. 被引量:3
-
5于小汇,王金华,王峰.特异性淋巴细胞转化试验评价致敏效果的可行性分析[J].中国误诊学杂志,2006,6(21):4117-4119. 被引量:3
-
6吴文川,靳大勇.MUC1 DNA疫苗治疗胰腺癌的研究进展[J].中华实验外科杂志,2007,24(4):511-512. 被引量:4
-
7袁时芳,师长宏,晏伟,姚青,李南林,王廷,王岭,张英起.人MUC1与GM-CSF基因融合真核表达质粒的构建与表达[J].细胞与分子免疫学杂志,2007,23(1):18-20.
-
8袁时芳,师长宏,姚青,李南林,王廷,王岭,张英起.MUC1基因疫苗和GM-CSF对小鼠的细胞免疫和体液免疫应答[J].第四军医大学学报,2007,28(17):1537-1540. 被引量:4
-
9戎叶飞,徐彬,靳大勇.MUC1在肿瘤发生发展及诊断治疗中的研究进展[J].复旦学报(医学版),2008,35(1):156-158.
-
10戎叶飞,靳大勇,吴文川,楼文晖,秦新裕.MUC1-VNTR基因修饰树突细胞对胰腺癌细胞株体外杀伤效应的研究[J].外科理论与实践,2008,13(3):227-230. 被引量:1
-
1钟少文,江慧玲,刘晓雁.滑石粉治疗乳腺癌术后淋巴瘘32例[J].中国中西医结合外科杂志,2004,10(2):108-109. 被引量:5
-
2白静,向小庆,叶红.细胞外基质金属蛋白酶诱导因子与宫颈癌的关系研究进展[J].实用医学杂志,2013,29(7):1183-1185.
-
3贝政平,夏英宗.怎样为肿瘤定性[J].祝您健康,1996,0(5):35-35.
-
4罗政.癌症疼痛的治疗进展[J].现代诊断与治疗,2003,14(5):290-291. 被引量:24
-
5汪斌,丁佑铭.原发性胆囊癌基因研究现状[J].世界华人消化杂志,2009,17(27):2811-2820. 被引量:2
-
6马丽,韩晓红,石远凯.非小细胞肺癌中预测疗效和评价预后的分子标志物研究进展[J].癌症进展,2010,8(3):223-229. 被引量:3
-
7刘健民,刘日华,等.中西医结合防治鼻咽癌的研究进展[J].国医论坛,2002,17(1):49-50.
-
8李杰,梁萍.彩色多普勒超声和超声造影在肝脏占位性病变中的应用进展[J].消化外科,2002,1(5):377-380. 被引量:9
-
9胡书生,孙立新,孙力超,韩璐璐,杨治华,冉宇靓,齐军.血清MCP-1在结直肠癌肝脏转移诊断及预后判断中的作用[J].中国肿瘤,2013,22(4):312-316. 被引量:5
-
10吴静,黄俊星,赵国军,詹树东,卢婷,周彤敏,于鸿.食管鳞癌组织中黑色素瘤相关抗原D4b的表达及临床意义[J].现代肿瘤医学,2015,23(15):2132-2135. 被引量:2