剥脱综合征临床分析

Clinical analysis of 34 paticnts with Pseudoexfoliation syndrome

目的探讨剥脱综合征（PEX）的临床表现及其特点,寻求有效的治疗途径。方法对34例49眼剥脱综合征患者的临床资料进行分析。结果最小发病年龄61岁,平均73岁。全部伴有不同程度的白内障。就诊时眼压已超过21mmHg者占全部PEX眼的55.1%,而已经发生青光眼性视野改变者也达到了全部视野检查的PEX眼的48.48%。25眼行超声乳化白内障摘除手术前后平均眼压分别为24.41mmHg和17.23mmHg。结论剥脱综合征是一种老年性的、以纤维状物质在许多眼部组织中的产生和进行性蓄积为特征的细胞外基质代谢紊乱性疾病。开角型青光眼发生风险大,在青光眼早期对所伴有的影响视力的白内障施行超声乳化摘除术可能会阻止其青光眼的进展。所伴青光眼病理过程严重,需要滤过手术介入。提高对本病的认识是避免延误其所伴青光眼治疗以及预防各种手术并发症风险的重要因素。

Objective To evaluate clinical featrures and examination and management of Pseudoexfoliation syndrome.Methods The clinical records of 34 cases（49 eyes） with Pseudoexfoliation syndrome were analized retrospectively. Results Among the 34 cases of Pseudoexfoliation syndrome, the youngest age was 61 years and mean age was 73 years. Lens opacity was found in all the patients.27 eyes were found with the lOP over 21mmHg（55.1% of all PEX eyes）.Glaucoma visual field were found in 48.48% of PEX eyes which visual field examination were taken.The lOP of 26 eyes on which phaco were performed are respectively 24.41mmHg and 17.23mmHg. Conelusion Pseudoexfoliation syndrome is an-related generalized fibrotic matrix process, which may cause severe chronic open-angle glaucoma and cataract, phacoemulsification is effective in prohibiting progress of glaucoma for exfoliation syndrome and exfoliative hypertension with no optic nerve damage, but for extbliative glaucoma with advanced optic nerve damage, the filtrating surgery should be reasonable option. Early recognition and emphasis on the process is very important to avoid delay of glaucoma treatment and occur rence of surgical complications,occurrence.