PI-3K/Akt通路的下游因子磷酸二酯酶3B及其临床研究

Phosphodiesterase Type 3B:Downstream Factor of PI-3K/PKB Pathway as well as Its Clinical Research

在胰岛素诱导的PI-3K/Akt通路中,磷酸二酯酶3B(phosphodiesterase type3B,PDE3B)作为Akt的下游因子,通过调控胞内cAMP浓度,来调节抗糖原水解、抗脂解以及葡萄糖转运等一系列生理过程。最近研究表明PDE3B的活性及表达的变化是产生胰岛素抵抗的关键因素之一。因此,PDE3B及影响PDE3B活性的一些物质将可能成为治疗2型糖尿病、肥胖症等以胰岛素抵抗为病理基础疾病的重要靶因子。

In the insulin-induced PI-3K/Ak pathway, phosphodiesterase type 3B（PDE3B）, as downstream factor of Akt, plays an important role in the physiological responses such as antiglycogenolysis, antilipolysis, glucose transport by mediating intracellular cAMP level. Recent evidence suggests that variety of PDE3B＇s activity and expression is one of key factors which lead to insulin resistance. Therefore, PDE3B and some substances affecting activity of PDE3B could be the target to cure .Type 2 diabetes and adiposity which pathophysiology are based on insulin resistance.