Mitotic Catastrophe的研究进展

Progress in Mitotic Catastrophe

细胞死亡是多细胞生物生命过程中重要的生理或病理现象,可分为坏死和程序性细胞死亡,而后者根据死亡细胞的形态学和发生机制的不同又可分为凋亡、自吞噬和mitotic catastrophe,其中mitotic catastrophe是近年来才被揭示报道,是指细胞在有丝分裂过程中死亡的现象,是一种发生在细胞有丝分裂期由于异常的细胞分裂而导致的细胞死亡,它常常伴随着细胞有丝分裂检查点的异常和基因或纺锤体结构的损伤而发生。现对mitotic catastrophe及相关的调控机制进行综述。

Cell death is an important physiology and pathology phenomenon to the multi-cellular organisms. The cell death can be categorized into necrosis and programmed cell death （PCD）. PCDs include apoptosis, autophagic cell death and mitotic catastrophe, each with different morphological changes and biochemical mechanistic pathways. The mitotic catastrophe was most recently recognized and described, and it characterizes as a cell death occurred during mitosis due to abnormal mitotic progress, usually accompanying with abnormal cell cycle checkpoint and genomic or spindle lesion. Herein we review the related molecular mechanisms regulating the mitotic catastrophe.