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Rho signaling inhibitor,Y-27632,inhibits invasiveness of metastastic hepatocellular carcinoma in a mouse model 被引量：3

Rho signaling inhibitor,Y-27632,inhibits invasiveness of metastastic hepatocellular carcinoma in a mouse model
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摘要 Hepatocellular carcinoma(HCC)is among the mostcommon tumors worldwide.Despite extensiveexploration of novel therapies,the prognosis of HCCpatients with intrahepatic metastasis is still poor,and notreatment is effective against metastases.Therefore,more effective therapeutic strategies for treatment ofmetastasis are urgently needed. Hepatocellular carcinoma （HCC） is among the most common tumors worldwide. Despite extensiveexploration of novel therapies, the prognosis of HCC patients with intrahepatic metastasis is still poor, and no treatment is effective against metastases. Therefore, more effective therapeutic strategies for treatment of metastasis are urgently needed.
作者 XUE Feng ZHANG Jian-jun QIU Feng ZHANG Ming CHEN Xiao-song LI Qi-gen HAN Long-zhi XI Zhi-feng XIA Qiang
机构地区 Organ Transplantation Center
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2007年第24期2304-2307,共4页 中华医学杂志（英文版）
关键词 ROCK inhibitor hepatocellular carcinoma METASTASIS apoptosis INVASIVENESS 肝细胞癌 肿瘤转移 细胞凋亡 信号抑制剂 Y-27632
分类号 R735.7 [医药卫生—肿瘤]
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参考文献10

  • 1Takamura M,Sakamoto M,Genda T,Ichida T,Asakura H,Hirohashi S.Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632[].Hepatology.2001
  • 2Itoh,K,Yoshioka,K,Akedo,H,Uehata,M,Ishizaki,T,Narumiya,S.An essential part for Rho-associated kinase in the transcellular invasion of tumor cells[].Nature Medicine.1999
  • 3Mukai,M,Endo,H,Iwasaki,T,Tatsuta,M,Togawa,A,Nakamura,H,Inoue,M.RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells[].Biochemical and Biophysical Research Communications.2006
  • 4Bartolome,R. A.,Molina-Ortiz,I.,Samaniego,R.,Sanchez-Mateos,P.,Bustelo,X. R.,Teixido,J.Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion[].Cancer Research.2006
  • 5Sawada S,Murakami K,Yamaura T,Mitani N,Tsukada K,Saiki I.Therapeutic and analysis model of intrahepatic metastasis reflects clinical behavior of hepatocellular carcinoma[].Japanese Journal of Cancer Research.2002
  • 6Horiuchi A,Imai T,Wang C,Ohira S,Feng Y,Nikaido T, et al.Up-regulation of small GTPases,RhoA and RhoC,is associated with tumor progression in ovarian carcinoma[].Laboratory Investigation.2003
  • 7Simpson KJ,Dugan AS,Mercurio AM.Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma[].Cancer Research.2004
  • 8Faried,A,Faried,LS,Kimura,H,Nakajima,M,Sohda,M,Miyazaki,T,Kato,H,Usman,N,Kuwano,H.RhoA and RhoC proteins promote both cell proliferation and cell invasion of human oesophageal squamous cell carcinoma cell lines in vitro and in vivo[].European Journal of Cancer.2006
  • 9Rattan,R,Giri,S,Singh,AK,Singh,I.Rho/ROCK pathway as a target of tumor therapy[].Journal of Neuroscience Research.2006
  • 10Benitah,SA,Valeron,PF,Lacal,JC.ROCK and nuclear factor-kappaB-dependent activation of cyclooxygenase-2 by Rho GTPases: effects on tumor growth and therapeutic consequences[].Molecular Biology of the Cell.2003

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Chinese Medical Journal
2007年 第24期

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