摘要
目的:检测乳腺癌中趋化因子受体CCR7的表达及其临床意义。方法:收集65例根治性切除的乳腺癌标本,用免疫组织化学法检测CCR7的表达,分析CCR7的表达与乳腺癌患者临床病理特征之间的相关性。结果:65例标本中,42例存在CCR7的高表达(64.6%),CCR7的表达与乳腺癌患者的淋巴结转移、TNM分期和肿瘤组织中淋巴细胞的浸润程度密切相关,但与淋巴结转移的数目无关。结论:趋化因子受体CCR7与乳腺癌淋巴结转移密切相关,其在乳腺癌的临床诊治中有参考价值。
Objective：To detect the expression and its value of CCR7 in breast cancer. Methods：CCR7 expression was investigated by means of immunohistochemistry in 65 patients with breast cancer who underwent radical mastectomy. The correlation of CCR7 expression and other clinical features was analyzed. Results：CCR7 receptor was expressed in 42 cases （64.6%）. The CCR7 expression was significantly associated with lymph node metastasis, stage and lymphocyte infiltration. But the number of metastatic lymph node was not associated with the expression of CCR7. Conclusion：CCR7 receptor plays an important role in the lymph node metastasis in breast cancer, which could be used in the clinical practice of breast cancer.
出处
《临床肿瘤学杂志》
CAS
2007年第12期906-908,共3页
Chinese Clinical Oncology
基金
云南省教育厅资助项目(No.06Y143C)
