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雌激素和三苯氧胺对MCF-7乳腺癌细胞Akt表达的影响及其意义 被引量：3

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摘要 为探讨雌激素和三苯氧胺对乳腺癌细胞Akt表达的影响。作者采用Western blot和免疫组化法检测上述两种药物作用下Akt的表达。结果示,三苯氧胺作用后Akt的表达明显高于对照组和雌激素组,以后者的表达为最低。提示:Akt的激活状态可能是乳腺癌内分泌治疗中产生耐受的重要机制之一,其有可能作为治疗的新靶点。
作者 王秀玲 益莉娜 丁佩芬 邹珏 洪月琳 郑唯强
机构地区 上海市第七人民医院病理科 上海市第七人民医院外科 第二军医大学长海医院病理科
出处 《中国普通外科杂志》 CAS CSCD 2007年第12期1197-1199,共3页 China Journal of General Surgery
基金 上海浦东新区社会发展局卫生科技资助项目(PW2006A-24)
关键词 乳腺肿瘤/药物疗法 AKT 信号转导 内分泌治疗
分类号 R737.9 [医药卫生—肿瘤]
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参考文献14

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共引文献13

同被引文献58

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引证文献3

二级引证文献5

中国普通外科杂志
2007年 第12期

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