不孕家庭支原体感染调查及药敏分析

Investigation on mycoplasma infection and drug resistance for barren families

目的了解不孕家庭支原体感染及抗菌药物治疗的药敏情况,为临床诊断和合理治疗提供科学依据。方法男性取精液、女性取宫颈拭子送检,进行培养及药敏试验。结果68个不孕家庭中23个家庭有支原体感染,占33.8%。在感染家庭中,男性20例占87%,女性23例占100%,女性高于男性。其中解脲支原体22例,占感染者的95.7%,人型支原体仅1例占感染者的4.3%。10种抗菌药物药敏试验结果表明,阿奇霉素和交沙霉素敏感率较高,达95%以上。林可霉素和罗红霉素敏感率较低,均未达到50%。结论在诸多不孕因素中支原体感染已占33.8%。应引起临床医生的高度重视。该地区以解脲支原体感染为主。抗菌药物应在药敏试验结果指导下使用或首选阿奇霉素和交沙霉素。

Objective To investigate mycoplasma infection and drug resistance for barren families, so as to provide scientific evidence for clinical diagnosis and rational therapy. Methods The samples of semen （males） and cervical swab （for females） were collected. Bacteria culture and drug resistance were performed. Results Of 68 barren families, 23 barren families showed mycoplasma infection （33.8 %）. In the infected families, males accounted for 20 （87%）, and females 23 （100%） with a higher infection rate. Ureaplasma urealyticum （UU） were 22 strains （95.7%）, and M. humenis （MH） was 1 strain （4. 3%）. Drug resistance test indicated that sensitive rate was higher to azithromycin and josamycin （〉9 5%）, lower to lincomycin and roxithromycin （〈 50%）. Conclusion In the risk factors for barren, mycoplasma infection accounts for 33.8%. It should be paid more attention to in clinical therapy. The antibiotics should be used rationally according to drug resistance results. Or else azithromycin and josamycin are used as the first chioce.