摘要
探讨血管内皮生长因子受体(VEGFR3)在结肠癌淋巴结转移中的意义。对99例术后结肠癌及其癌旁组织石蜡包埋标本构建组织芯片并进行免疫组织化学染色,探测其表达强度并结合临床资料进行分析。结果表明结肠癌细胞表达VEGFR3与Duke’s分期有关,Duke’s C,D期结肠癌细胞表达VEGFR3较Duke’s A.B期显著升高(P<0.01),与局部淋巴结转移相关(P<0.05)。癌与癌旁组织表达差异显著(P<0.01)。分化良好者与分化不良者表达差异显著(P<0.01)。结论:结肠癌随病情加重,肿瘤细胞表达VEGFR3与诱发局部淋巴结转移相关。
To evaluate the relationship between vascular endothelium growth factor receptor 3 （VEGFR3） and lymph node metastasis in colon cancer patient, tissue microarray was constructed by post-operation colon cancer paraffin-embedded specimen in 99 cases and underwent immunohistochemistry staining, and its expression intensity was detected and analyzed with clinical data. The results showed that the expression of VEGFR3 in colon cancer cell in Duke＇s C and Duke＇s D was obviously stronger than that in Duke＇s A and B（P〈0.01）, and correlated with the local lymph node metastasis （P〈0.05）. The expression intensity of VEGFR3 in cancer cell was much stronger than that in para-tumor tissue（P〈0.0l）. There was significant difference in the expression of VEGFR3 between well-differentiated and poor-differentiated colon cancer tissue. With exacerbation of colon cancer, the expression of VEGFR3 in tumor cell is related to local lymph node metastasis.
出处
《标记免疫分析与临床》
CAS
2007年第4期203-206,共4页
Labeled Immunoassays and Clinical Medicine
