摘要
通过应用改良的单管酸水解法合成2-^(18)F-2-脱氧-β-D-葡萄糖(^(18)F-FDG),提高^(18)F-FDG的合成效率。采取不同反应温度、合成时间及其他生产条件,观察用单管盐酸水解法合成^(18)F-FDG的合成效率,探索出最佳生产条件。合成体系中的含水量是最终影响合成效率的主要因素,通过有效除水可以缩短合成时间;调整盐酸用量,可以缩短水解时间,从而提高合成效率。通过对原有合成程序中某些生产条件的改善,可以大大缩短合成时间,提高^(18)F-FDG合成效率。
In order to explore an optimum condition to increase the synthesis yield of 2-18 F-2-deoxy-β-D-glucose （18 F-FDG） by using improved single-pot acid hydrolysis Chemistry Process Control Unit （CPCU）, various production conditions such as the reaction temperature, the time of acid hydrolysis and others were tested. The results showed that the determinant factor which affects the synthesis yield was the quantities of water present in reaction media. The to- tal 18 F-FDG synthesis time could be minimized by effective dehydration step and regulating the amount of hydrogen chloride. The synthesis yield could be increased by improving the production conditions of 18 F-FDG.
出处
《标记免疫分析与临床》
CAS
2007年第4期234-237,共4页
Labeled Immunoassays and Clinical Medicine
