地西泮静脉注射治疗木僵状态

Treat stupor state by diazepam

目的探讨使用地西泮静脉注射治疗木僵状态的方法及疗效。方法停用其他抗精神病药物,检查患者躯体健康状况良好,静脉注射地西泮(首次15～20 mg,次日20～30 mg);收集同期经舒必利(300～400 mg)静脉滴注的类似病例,采用症状量表评定治疗前后症状,对结果进行统计分析。结果19例患者短时间内可改善木僵状态,未发现其他不良反应,而舒必利静脉滴注组1周内仅2例显著进步,12例轻度好转,5例无效;1周内两组显效差异有统计学意义(P<0.05)。结论地西泮治疗木僵状态成本低、不良反应少且疗效佳,是一种安全可行的疗法。

Objective To explore the efficacy and method of diazepam in the treatment of stupor state. Methods Other antipsychotic drugs were stopped using patients were made sure to be healthy,inject with diazepam （first day 15- 20mg,second day 20- 30mg）. Then, the similar patients who infused with sulpiride（300- 400mg everyday） were collected during the same period, all the cases were evaluated by SAPS and SANS. Analysis the results by t-test. Results After injecting diazeparn,19 patients＇ stupor state were improved in a short time,and didn＇t appear adverse reaction. But after using sulpifide,only 2 cases improved, 12 cases were better and 5 cases had no change,there were significant difference between two groups during the first week. Conclusion Using diazepam for stupor state is a safe and feasible treatment, with low cost ,slight adverse reaction but high efficacy.