摘要
A convenient synthesis of optically active α, α -diphenyl-2-pyrrolidinemethanol (1)starting from L-proline, based on different N-protections, was described. Different N-pro-tections had no effect on the optical purity of compound 1, but gave different chemical yields. The yield was the lowest when PhCH2, was employed for N-protection. An investiga-tion on the effect of N-protection on the chemical yield and the optical purity of compound 1led to a convenient preparation of the new chiral oxazolidinone 3. The structure of 3 was identified with 1H NMR, 13C NMR, MS and IR.
A convenient synthesis of optically active α, α -diphenyl-2-pyrrolidinemethanol (1)starting from L-proline, based on different N-protections, was described. Different N-pro-tections had no effect on the optical purity of compound 1, but gave different chemical yields. The yield was the lowest when PhCH2, was employed for N-protection. An investiga-tion on the effect of N-protection on the chemical yield and the optical purity of compound 1led to a convenient preparation of the new chiral oxazolidinone 3. The structure of 3 was identified with 1H NMR, 13C NMR, MS and IR.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1997年第6期911-913,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
国家教育委员会优秀年轻教师基金
博士点基金
关键词
合成
恶唑烷酮
二苯基
吡咯烷甲醇
Synthesis, α, α'-Diphenyl-2-pyrrolidinemethanol, Oxazolidinone
