摘要
磷脂酰肌醇3-激酶(PI3K)及其下游分子AKT、TSC1/2和mTOR所组成的信号通路参与增殖、凋亡等多种细胞功能的调节。近年来发现,这一信号通路与细胞的分化密切相关。细胞分化的异常可以引起多种疾病,肿瘤就是一种分化异常的疾病,而PI3K-AKT-mTOR信号传递通路调节失常在肿瘤中最为常见,因此本文旨在综述PI3K-AKT-mTOR信号通路在细胞分化和肿瘤中的作用。
Phosphatidylinositol-3-kinase （PI3K）, AKT, TSC1/2, and the mammalian target of rapamycin （mTOR） signaling cascade involves many cellular processes including apoptosis, growth, proliferation and differentiation, This pathway has been found to be the most variable one in human tumors. As tumor is a poorly differentiated disease, this review examines the role of the PI3K-AKT signal pathway in cell differentiation and tumor development.
出处
《基础医学与临床》
CSCD
北大核心
2007年第12期1404-1408,共5页
Basic and Clinical Medicine
基金
国家自然科学基金(30070284)
