恶性综合征的临床分析与预后探讨

Clinical analysis and prognosis of neuroleptic malignant syndrome

目的探讨恶性综合征(neuroleptic malignant syndrome,NMS)的临床特点与预后,提高临床工作者对本综合征的认识。方法对17例NMS患者进行临床评价。结果①17患者均有肌强直、高热、肌酸激酶值增高;②发病3 d内确诊者8例,全部存活;1周内未得到确诊者3例,全部死亡。结论NMS以肌强直、发热、肌酸激酶值增高为主要特征;避免误诊、早诊断早治疗是改善预后的关键所在。

Objective To study the clinical features and prognosis of neuroleptic malignant syndrome （NMS） in order to improve clinical workers understanding of NMS. Method 17 NMS patients were assessed. Result （1） All the 17 patients had the manifestation of hypertheralia, muscle rigidity and increased CK level; （2）8 patients were correctly diagnosed within the 3 days after the onset and survived; the 3 patients who did not get a correct diagnosis during the first week died. Conclusion NMS is mainly characterized by muscle rigidity, hyperthermia and increased CK level; avoiding misdiagnosis, early diagnosis and immediate treatment are the key of better prognosis.