湖州市门诊妇女HPV感染亚型的基因芯片检测及分析

Detection of the human papilloma virus genotypes of women in Huzhou using gene chips

目的了解湖州市门诊妇女人乳头瘤病毒(HPV)感染状况和感染型别,为宫颈癌的防治提供理论依据。方法对414例湖州市门诊妇女宫颈分泌物应用基因芯片技术进行18种高危型和5种低危型HPV亚型检测。结果414例妇女中共检出HPV阳性97例,占23.43%,其中单一感染76例,占18.35%;双重感染17例,占4.11%;三重及以上感染4例,占0.97%。97例阳性患者中有高危型HPV感染的为80例,占HPV总阳性人数的82.47%。阳性患者中高危型以16、18、33为主,检出率分别为4.35%、2.17%、2.17%;低危型以6、11型为主,检出率分别为1.69%和1.45%。结论湖州市门诊妇女HPV感染有相当比例,且高危型HPV感染率在总阳性患者中所占比例较高。因此,对门诊妇女有必要进行HPV感染筛查,及早发现高危人群,并进行随访和相应治疗,以降低宫颈癌的发病风险。

Objective To understand human papilloma virus （HPV） infection situation of women in Huzhou. Methods HPV genotypes of 414 women in Huzhou were examined by gene chip technique. Results Among the total 414 cases ,97 cases were HPV positive（23.43 % ）, 76 cases（ 18.35% ） were single ttPV type infection and 17 cases（4.11% ） were double HPV types infection and 4 cases（0.97% ） were multiple HPV types infection respectively. In 97 ttPV positive cases, the detecting to- tal rates of high risk HPV geuotypes were 82.47 % （80/97）. The major low risk HPV genotypes were 6,11, and most high risk HPV genotypes were 16,18,33. Conclusion The gene chip technique is a sensitive and specific method for examining HPV. In the ttuzhou city, HPV infection is quite a few in women, furthermore, the infection of high risk genotypes occupy a big proportion. It shouht be very important to detect HPV -DNA in women and control the HPV infection, the risk of cervical cancer maybe decrease as hope.