摘要
[目的]探讨清热祛湿法对肝纤维化大鼠肝细胞凋亡的影响。[方法]采用复合因素诱导肝纤维化大鼠模型,期间每日灌服清热祛湿法代表方清香散,6周后,观察清热祛湿法对肝细胞凋亡的影响。[结果]清热祛湿法能明显减少肝纤维化大鼠肝细胞凋亡的数目(P<0.01)。[结论]清热祛湿法能明显抑制肝细胞凋亡,其抗凋亡效应可能通过抑制肝细胞或肝星状细胞分泌转化生长因子β1实现。
Objective To measure the influence of eliminating heat and wetness evil（EHAWE） therapy on hepatocyte apoptosis in liver fibrosis rat model.MethodsThe fibrosis rat model was induced by multiple factors and was given QingXiangSan.At the end of the sixth week, the influence of EHAWE therapy on hepatocyte apoptosis was observed.Results EHAWE therapy could obviously decrease the hepatic cells apoptosis in fibrosis rat liver.Conclusion EHAWE therapy can markedly inhibit the hepatic cells apoptosis by reducing the expression of TGF-β1 from hepatocyte or HSC.
出处
《中国中西医结合消化杂志》
CAS
2007年第6期367-368,共2页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
广东省中医药局滚动资助项目(303012)
关键词
清热祛湿法
肝纤维化
肝细胞凋亡
转化生长因子Β1
eliminating heat and wetness evil therapy
liver fibrosis
apoptosis
transforming growth factor-beta 1
