烧伤病房728株感染病原菌的分布特点及耐药性分析

Investigation of 728 strains of infectious bacteria in burn ward and analysis of their antibiotic resistance

目的了解笔者单位近5年烧伤感染病原菌的分布特点及耐药情况。方法收集2001—2006年笔者单位306例烧伤患者创面分泌物等标本中分离的病原菌,对其菌种分布特点及耐药性进行分析。结果革兰阳性菌378株,其中金黄色葡萄球菌的菌株数居首位,尤以甲氧西林耐药金黄色葡萄球菌居多,表皮葡萄球菌和粪肠球菌的菌株数分别位居第2、3位。革兰阴性杆菌338株,其中鲍氏不动杆菌的菌株数居首位,阴沟肠杆菌和铜绿假单胞菌的菌株数分别位居第2、3位。检出真菌12株。结论笔者单位病原菌的分布情况,可能与甲氧西林耐药葡萄球菌呈多重耐药性以及鲍氏不动杆菌产生各种类型的β内酰胺酶有关。

Objective To study the infectious strains of bacteria in our burn ward in recent 5 years, and analyze their antibiotic resistance. Methods Bacteria were isolated from the wound excretions of 306 burn patients hospitalized during 2001 to 2006 for analyzing their strains and their antibiotic resistance. Results 378 strains were Grams positive bacteria , among them Staphylococcus aureus was the predominant strain. Further analysis showed that methicillin resistant staphylococcus aureus（MRSA） ranked the first in occurrence, followed by methicillin-resistance Staphylococcus epidermidis（MRSE） and Enterococcus fecalis, 338 strains were Gram negative bacteria, and among them Acinetobacter baumannii was predominant, and Enterobacter cloacae and Pesudomonas aeruginosa ranked the 2z^nd and 3rd. Twelve strains were fungis. Conclusion Drug resistance to antibiotics in our burn ward may be related to the β-1actamases from acinetobacter baumannii and multiple-drug-resistance of MRSA.