HBeAg阳性和HBeAg阴性慢性乙型肝炎患者肝组织病理对比分析

A Comparison of the grading of the Liver Pathology between HBeAg-positive and HBeAg-negative Chronic Hepatitis B

目的探讨HBeAg阳性和HBeAg阴性慢性乙型肝炎(CHB)患者肝组织病理炎症活动度分级和纤维化分期以及与临床的关系。方法对我院近年收治的1112例有肝穿病理资料的慢性乙型肝炎患者进行分析,比较HBeAg阳性和HBeAg阴性CHB患者肝组织病理的分级分期及其与肝功能的关系。结果1112例慢性乙型肝炎患者HBeAg阳性706例(占63.49%),HBeAg阴性406例(占36.51%)。两组肝组织病理炎症活动度分级及纤维化分期比较差异无显著性(P值均>0.05)。两组患者丙氨酸氨基转移酶(ALT)与炎症分级比较差异无显著性(P>0.05)。结论无论HBeAg阳性或阴性慢性乙型肝炎患者肝脏炎症分级及纤维化分期比较差异均无显著性,肝组织病理损伤基本相同。

Objective To study the degree of damage caused by liver-tissue inflammation and fi- brosis and their clinical relationships between HBeAg-positive and HBeAg-negative Chronic Hepatitis B. Methods To compare the grading of liver-tissue pathology between the two groups and to analyze their relationship with liver function by analyzing the records of 1112 chronic hepatitis B （CHB） patients who had experienced liver biopsy in our hospital. Results Of 1112 cases ,706 are HBeAg-positive （63.49%） and 406 are HBeAg-negative （36.51%）. No significant differences were found in the grade of inflammatory activity and their fibrotic stage （P 〉 0.05 ） by the liver biopsy. Alanine aminotransferase （ALT） and grade of inflammatory activity also had no significant differences （ P 〉 0.05 ）. Conclusion Whether the CHB patients are HBeAg-positive or negative, the degree of their liver inflammatory activity and fibrotic stage have no statistical significance.