39例慢性肾衰竭患者认知功能下降的调查

A preliminary investigation of cognitive dysfunction in chronic renal failure patients

目的通过神经心理测试等手段,探讨慢性肾衰竭(CRF)患者的认知状态。方法对39例40～60岁临床确诊为慢性肾衰竭的患者进行神经心理测试及人格和情绪状况测查,并对认知状态进行整体评定及分析。结果慢性肾衰竭患者认知功能测验成绩均低于对照组,并与人格的"精神质"和"情绪性"、健康自评等心理因素有关。"精神质"和"情绪性"越强,健康自评越差,认知障碍就越严重。慢性肾衰竭患者的焦虑和抑郁程度比对照组严重。结论慢性肾衰竭患者存在着认知能力下降,且与躯体和心理因素有关,并且随着肾功能的恶化,这种表现更加明显。

Objection To explore the cognitive function and related factors in patients with chronic renal failure by neuropsychological tests. Methods 39 patients with chronic renal failure and 39 healthy controls with similar demographic characteristics were recruited. Neuropsychological test was ad- ministered in both groups. The personality and affective states were assessed, and the correlated factors between cognitive function and creatinine,urea nitrogen,ferrohemoglobin or electrolure were also analysed. Results The scores of cognitive tests in patients with chronic renal failure were significantly lower than those in control group. The cognitive impairments were closely related to decreased blood perfusion in frontal and temporal lobes. Patients with chronic renal failure were more depressive and anxious than controls. Conclusion Patients with chronic renal failure have some cognitive dysfunction which are related to physical and psychological factors.