动脉时辰化疗治疗大肠癌肝转移的临床研究

The Clinical Research of Intra-Arterial Chrono-Chemotherapy in Liver Metastases from Colorectal Cancer

目的:研究动脉时辰化疗在治疗大肠癌肝转移中的临床意义。方法:将42例病人随机分为两组,分别行动脉时辰化疗及动脉恒速化疗,观察其临床副反应及疗效。结果:两组患者重度恶心呕吐和肝功能损害发生的频率具有显著性差异(P<0.05),动脉时辰化疗较恒速化疗副反应降低,近期疗效无明显差异(P>0.05)。结论:动脉时辰化疗较常规动脉恒速化疗副反应轻微,耐受性好,是治疗大肠癌肝转移的有效方法。

Objective： To study the clinical significance of intra - ＇arterial chrono - chemotherapy in liver metastases from colorectal carcinoma. Methods： 42 patients with liver metastases from colon carcinoma were divided into two groups, chrono - chemotherapy and regular chemotherapy were given to the two groups respectively. The toxic effects and the clinical effects were observed.Results： There were significant difference between the two groups on severe nausea and damage of hepatic function（P 〈 0.05）, the chrono - chemotherapy group has slight toxic effects than the regular chemotherapy group. On the short term observing, and there were no difference between two group（ P 〉 0.05）. Conclusion： The chrono - chemotherapy had slight toxic effects and better acceptance, it was the effective treatment in liver metastases from colorectal cancer.