重组人表皮生长因子对面部Ⅱ度烧伤创面修复的临床观察

Clinical Study of the Repair of Second Degree Facial Burns Using Recombinant Human Epidermal Growth Factor

目的:观察外用重组人表皮生长因子(rhEGF)对面部Ⅱ度烧伤创面的治疗作用和安全性。方法:选择面部浅Ⅱ度、深Ⅱ度烧伤患者各28例,每例患者选择一块浅Ⅱ度、深Ⅱ度烧伤创面,并将其分为面积相近的两部分作为治疗组及对照组;伤后第3天起,治疗组采用含rhEGF的等渗盐水纱布覆盖创面,对照组单用等渗盐纱布覆盖创面,每日换药1次至创面愈合。观察应用rhEGF后面部浅Ⅱ度、深Ⅱ度烧伤创面中期愈合率、愈合时间、疼痛情况及Ⅱ度创面愈合后的瘢痕指数。结果:治疗组与对照组相比创面愈合速度加快,愈合时间缩短(P<0.01),同期愈合率提高(P<0.01);未见疼痛加重;能明显减少瘢痕的形成;治疗过程未见明显毒副作用及不良反应。结论:外用rhEGF能加快面部Ⅱ度烧伤创面的愈合速度,缩短愈合时间,提高愈合质量,减少瘢痕的形成,无明显不良反应,安全性好。

Objective： To explore the therapeutic effect and security of recombinant human epidermal growth factor（rhEGF） for the facial burn wounds of degree Ⅱ. Methods： 28 cases of facial superficial degree Ⅱ burn patients and 28 cases of facial deep degree Ⅱ bum were selected.An area of superficial and deep degree Ⅱ burn wounds from each patient was harvested and divided into treatment group and control group with the same portions. From the third day, the wound in the treatment group was treated with rhEGF saline gauzes, while the control group with normal saline gauzes .The dressing was changed everyday until the wounds healing. Then to observe the healing rate ,healing time, pain degree and scar index. Results： The wounds healing in the treatment group was faster than the control group; the healing time was shorten （P 〈 0.01） ; and the healing ratio on synchronization was promoted （ P 〈 0.01） ; the pain in the treatment group was not exacerbated with less scars formation.No obvious side effects or adverse reaction was found during the treatment. Conclusions：rhEGF could accelerate obviously the speed of wounds healing,and shorten the healing time of the facial burn wounds of degree Ⅱ,meanwhile it could promote the healing quality with less scars formation.rhEGF was effective and safe for the wounds.