年轻发病的糖尿病临床分型分析

Clinical Analysis of Young-onset Diabetes Mellitus

对282例发病年龄在20～40岁的糖尿病患者进行回顾性分析。按临床表现及本次调查制定的标准将患者分为3组:IDDM、缓慢进展性胰岛素依赖型糖尿病(SPIDDM)、NIDDM组。对比分析结果显示:此年龄段发病初诊断的NIDDM中,至少有16％～26％应当属于SPIDDM。SPIDDM的发病年龄、体重指数、发病时血糖、胰岛素、HbA_1C以及酮症、DKA的发生率均与IDDM接近。因此,尽早发现SPIDDM患者并采取合理治疗,对保护残存胰岛功能,减少减慢并发症的发生有重要意义。

282 patients of young-onset (at 20-40 years old) of diabetes mellitus were analysed. They were divided into 3 groups: insulin-dependent diabetes mellitus(IDDM,79 cases),slowly progressive insulin-dependent diabetes mellitus (SPIDDM, 34 cases), and non-insulin-dependent diabetes mellitus (NID DM, 169 cases). The results showed that 16%-26% of the diabetic patients had the onset at age 20- 40 years who were eventually diagnosed as SPIDDM. The onset age,body mass index(BMI) .blood sugar, insulin, HbA1C, and the incidence of ketosis or ketoacidosis in the SPIDDM were similar to IDDM. Therefore it is important to detect SPIDDM early and make effort to protect them from islet damage.