N-取代双环哌啶的简便合成

A facile synthesis of N-substituted bispidine

由哌啶酮经过双Mannch和还原两步反应合成了5种N-苄基-N′-烷基双环哌啶化合物,并经波谱分析确定了它们的结构,为N-取代双环哌啶的合成提供了一条简便、有效的合成方法。

Five kind of N -benzyl -N＇-alkyl bispidine have been synthesized from piperidone in two steps involving double Mannich reaction, Their structures had been confirmed by spectrum analysis, It offered a faciled and effective synthesis method for N - substituted bispidine.