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I-超家族芋螺毒素研究进展 被引量：2

Progress on the Study of I-superfamily Conotoxins
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摘要 I-超家族芋螺毒素是芋螺毒素中较复杂的超家族之一,它可分为I1和I2两组.通常由33～46个氨基酸所组成,具有相同的4对半胱氨酸骨架,可特异性作用于各种离子通道及受体.现对该芋螺毒素的生物化学及分子生物学特征、生理学活性、结构与功能的关系及应用前景等方面的研究进行综述. Ⅰ-superfamily is one of the most complicated families among conotoxins, which is composed of two groups： Ⅰ1 and Ⅰ2. Usually, Ⅰ-superfamily conotoxins contain 33-46 amino acid residues with four disulfide bonds. These disulfide-rich peptides can potently and selectively interfere with ion channels or receptors. The biochemical characteristics, physiological functions, structure-function relationship, and application perspective of Ⅰ-superfamily conotoxins are reviewed.
作者 黄丽君 王春光 戚正武
机构地区 同济大学蛋白质所
出处 《生命科学研究》 CAS CSCD 2007年第4期283-288,共6页 Life Science Research
基金 国家"973"计划项目(2004CB719904)
关键词 超家族芋螺毒素 离子通道 二硫键 翻译后修饰 Ⅰ-superfamily conotoxins ion channel disulfide bond post-translational modification
分类号 Q516 [生物学—生物化学] Q71 [生物学—分子生物学]
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参考文献22

  • 1TERLAU H, OLIVERA B M. Conus venoms: a rich source of novel ion channel-targeted peptides[J]. Physiol Rev, 2004, 84: 41-68.
  • 2王承忠,蒋辉,戚正武.芋螺毒素研究进展[J].生物化学与生物物理进展,2003,30(4):537-545. 被引量：9
  • 3陈冀胜.药物开发的新领域——芋螺毒素[J].中国天然药物,2004,2(3):129-134. 被引量：5
  • 4BUCZEK O, YOSHIKAMI D, WATKINS M, et al. Characterization of D-amino-acid-containing excitatory conotoxins and redefinition of the I-conotoxin superfamily[J]. FEBS J, 2005, 272(16): 4178-4188.
  • 5FAN C X, CHEN X K, ZHANG C , et al. A novel conotoxin from Conus betulinus, kappa-BtX, unique in eysteine pattern and in function as a specific BK channel modulator[J]. J Biol Chem,2003, 278(15): 12624-12633.
  • 6KAUFERSTEIN S, HUYS I, LAMTHANH H, et al. A novel conotoxin inhibiting vertebrate voltagesensitive potassium channels[J]. Toxicon, 2003, 42( 1 ): 43-52.
  • 7JIMENEZ E C, SHETrY R P, LIRAZAN M, et el. Novel excitatory Conus peptides define a new conotoxin superfamily [J]. J Neurochem, 2003, 85(3): 610-621.
  • 8BUCZEK O, BULAJ G, OLIVERA B M. Conotoxins and posttranslational modification of secreted gene products [J]. Cell Mol Life Sci, 2005, 62: 3067-3079.
  • 9JACOBSEN R, JIMENEZ E C, CRUZ R G, et al. A novel D- leucine-containing Conus peptide: diverse conformational dynamics in the contryphan family[J]. J Peptide Res, 1999, 54(2): 93-99.
  • 10LOUGHNAN M, BOND T, ATKINS A, et al. a-Conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors[J]. J Biol Chem, 1998, 273(25): 15667-15674.

二级参考文献55

  • 1钟明鼐,陈冀胜.芋螺毒素研究进展[J].生命科学,1996,8(5):23-25. 被引量：3
  • 2Terlau H, Shon K J, Grilley M, et al. Strategy for rapid immobilization of prey by a fish-hunting marine snail. Nature,1996, 381 (6578): 148～151.
  • 3Olivera B M. E. E. Just Lecture, 1996. Conus venom peptides,receptor and ion channel targets, and drug design: 50 million years of neuropharmacology. Mol Biol Cell, 1997, 8 (11):2101～2109.
  • 4Olivera B M, Cruzab L J. Conotoxins, in retrospect. Toxicon,2001, 39 (1): 7～14.
  • 5Craig A G, Bandyopadhyay P, Olivera B M. Post-translationally modified neuropeptides from Conus venoms. Eur J Biochem, 1999, 264 (2): 271～275.
  • 6Jimenez E C, Craig A G, Watkins M, et al. Bromocontryphan: post-translational bromination of tryptophan. Biochemistry,1997, 36 (5): 989～994.
  • 7McIntosh J M, Santos A D, Olivera B M. Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes. Annu Rev Biochem, 1999, 68:59～88.
  • 8Ellison M, McIntosh J M, Olivera B M. α-conotoxins Im Ⅰ and Im Ⅱ, similar aα7 nicotinic receptor antagonists act at different sites. J Biol Chem, 2003, 278 (2): 757～764.
  • 9Dutton J L, Bansal P S, Hogg R C, et al. A new level of conotoxin diversity, a non-native disulfide bond connectivity in α-conotoxin AuIB reduces structural definition but increases biological activity. J Biol Chem, 2002, 277 (50): 48849～48857.
  • 10Shon K J, Grilley M, Jacobsen R, et al. A noncompetitive peptide inhibitor of the nicotinic acetylcholine receptor from Conus purpurascens venom. Biochemistry, 1997, 36 (31):9581～9587.

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生命科学研究
2007年 第4期

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