摘要
I-超家族芋螺毒素是芋螺毒素中较复杂的超家族之一,它可分为I1和I2两组.通常由33~46个氨基酸所组成,具有相同的4对半胱氨酸骨架,可特异性作用于各种离子通道及受体.现对该芋螺毒素的生物化学及分子生物学特征、生理学活性、结构与功能的关系及应用前景等方面的研究进行综述.
Ⅰ-superfamily is one of the most complicated families among conotoxins, which is composed of two groups: Ⅰ1 and Ⅰ2. Usually, Ⅰ-superfamily conotoxins contain 33-46 amino acid residues with four disulfide bonds. These disulfide-rich peptides can potently and selectively interfere with ion channels or receptors. The biochemical characteristics, physiological functions, structure-function relationship, and application perspective of Ⅰ-superfamily conotoxins are reviewed.
出处
《生命科学研究》
CAS
CSCD
2007年第4期283-288,共6页
Life Science Research
基金
国家"973"计划项目(2004CB719904)
关键词
超家族芋螺毒素
离子通道
二硫键
翻译后修饰
Ⅰ-superfamily conotoxins
ion channel
disulfide bond
post-translational modification