甘氨双唑钠(CMNa)对食管癌放射治疗增敏作用的临床观察

The Cinical Study of CMNa on Radiosensitivity-enhanced Effect Treating Esophageal Cancer

目的:初步评价甘氨双唑钠的放射增敏作用及其安全性.方法:各期食管癌病人65例,均符合入组条件并有病理证实,随机分为治疗组和对照组.治疗组病人常规放疗同时使用CMNa 800mg/m2用100 ml生理盐水稀释静点,每周3次,连续用至放疗结束.对照组用安慰剂加生理盐水.结果:治疗组的CR率高于对照组(P<0.05).治疗组病人治疗达到PR和CR时的中位照射剂量均低于对照组.但由于病例数少,未观察到统计学差异.结论:CMNa对食管癌有良好的放射治疗增敏作用,远期效果及安全性有待进一步的随诊观察.

Objective： To evaluate the radiosensitivity - enhanced function and safety of CMNa preliminarily. Methods ：65 patients with esophageal cancer were divided into two groups randomly： treatment group（A Group）and control group（B Group）. The patients in treatment group were infused with CMNa 800mg/m^2 via intravenous dripx diluted by 100ml physiological saline, triple a week during whole treatment period. The patients in eontol group received placebo and normal saline. Results： The CR rate of A Group was significantly higher than that of B Group （ P 〈 0. 05） .The median dose of A Group was lower than that of B Group before the PR and CR were reached. There was no difference between the two groups because of small sample - size. Conclusion ： CMNa increases the radiotherapeutic effect in the esophageal cancer. Further study on its remote effect and safety is warranted.