乙肝母婴阻断168例临床分析

Clinical Analysis on the Measures Interrupting Mother-to-baby Transmission of HBV:168 Cases Reports

目的:探讨乙型肝炎表面抗原(HBsAg)阳性母亲分娩新生儿实施母婴阻断的最佳方案.方法:通过总结通辽市传染病医院和通辽市铁路医院168例HBsAg阳性母亲分娩新生儿实施母婴阻断后的血清HBV标志物资料.根据不同阻断方案分成三组:重组酵母疫苗组、联合免疫组、宫内阻断组.结果:宫内阻断组保护率最高,达到96.0%.HBV宫内感染率最低;联合免疫组效果优于重组酵母疫苗组.结论:HBV母婴传播与母亲HBeAg或HBV-DNA阳性显著相关,免疫失败的重要原因是宫内感染,产前多次注射HBIG(高效价免疫球蛋白)可减少宫内感染.

Objective：To find out the best measure to interrupt mother- to- baby transmission of HBV for the pregnant women with positive HBsAg. Methods： Summarizing and analyzing the data of serous markers of HBV of 168 pregnant women with positive HBsAg in Tongliao city infectious diseases and railway hospitals. All patients were divided into 3 groups according to the interruption measures： via recombinant vaccine, combined immunization and intrauterine interruption. Results. The effective rate of intrauterine interruption amounted to 96.0 % and the newborn showed the lowest intrauterine infection rate. The effect of combined immunization was better than that of recombinant vaccine. Conclusion： There are close correlations between the mother - to - baby transmission rate and positive HBsAg and HBV- DNA. It can reduce the incidence of intrauterine infection by multiple prenatal injection of HBIG.