中效胰岛素(诺和灵N)分别联合瑞格列奈(诺和龙)和格列吡嗪(美吡达)的疗效观察

The effect comparison between NPH insulin(Novolin N) associated with Repaglinide(Novonorm) and NPH insulin(Novolin N) associated with Glipizide

目的比较中效胰岛素(诺和灵N)分别与瑞格列奈(诺和龙)和格列吡嗪(美吡达)联合治疗的疗效观察。方法将通过控制饮食和运动疗法加中效胰岛素(诺和灵N)治疗的不理想的2型糖尿病患者60例,随机分为治疗组和对照组各30例,疗效3个月。结果瑞格列奈(诺和龙)和格列吡嗪(美吡达)在降低空腹血糖(FBG)、餐后2h血糖(2hPG)和糖化血红蛋白(HbA1C)上无明显统计学差异(P>0.05),瑞格列奈(诺和龙)在降低甘油三酯方面与格列吡嗪(美吡达)有统计学差异(P<0.05)。结论瑞格列奈(诺和龙)具有降低血糖和甘油三酯的双重作用。

Objective To evaluate the effect of NPH insulin （Novolin N） combined with Repaglinide（Novonorm） and Glipizide in treating type 2 diabetes mellitus patients. Methods Through diets-exercise and treated with NPH insulin （Novolin N）,sixty patients with type 2 diabetes mellitus who did not obtain satisfactory improvement were randomly divided into 2 groups .After three months, thirty patients were treated with NPH insulin （Novolin N） and Repaglinide （Novonorm）,thirty controls were treated with NPH insulin （Novolin N） and Glipizide. Results To play down fasting blood glucose, 2h blood glucose and HbAlC, Repaglinide（Novonorm） and Glipizide had not significant difference（P〉0.05）.To reduce triglyceride（TG）, Repaglinide（Novonorm） and Glipizide had significant difference（P〈 0.05）.Conclusion Repaglinide（Novonorm） had two effects of reducing blood glucose and triglyceride（TG）.