摘要
本文测定了15例肝硬化、15例原发性肝癌病人的血清铜及铜／锌比值，并与17例正常人血清铜及铜／锌比值相比较，结果发现：①肝硬化和肝癌组病人血清锌水平低于正常对照组（分别为15．94±0．06和15．44±9．92μmol／L），但两组患者之间无显著性差异（P＞0．05）；②肝硬化组和肝癌组病人的血清铜水平均高于对照组，肝癌组病人的血清铜水平又显著高于肝硬化组（分别为31．92±0．07μmol／L和20．25±0．06μmol／L，P＜0．001），而肝硬化组与正常组血清铜水平差异不显著（20．25±0．06μmol／L和17．35±2．75μmol／L，P＞0．05）；③肝硬化组和肝癌组病人的血清铜及铜／锌显著高于对照组（分别P＜0．05和P＜0．001）．两组病人之间的血清铜／锌值有显著性差异（P＜0．001）。提示血清铜及铜／锌的测定有助于肝硬化和肝癌的鉴别诊断。
15 cases with cirrhosis and another 15 with hepatic cancer received test about their serum copper and copper/zinc value, which was contrasted with 17 healthy sujects as controls. The results show that:①The serum zinc levels in the two patient groups were lower than the controls (15. 94±0. 06pmol/L and 15. 44±0.02pmol/L respectively), but there is no significant difference within the patient groups (P>0. 05). ②The serum copper level in the two patient groups was higher than that in controls, and hepatic cancer group was significantly higher than cirrhotic group (31. 92±0. 07μmol/L vs 20. 25± 0. 06μmol/L P<0. 001 ), cirrhotic group has no significant difference as compared with controls (20. 25±0. 06μmol/L vs 17. 35± 2. 75μmol/L P>0. 05),and 3) The serum copper/zinc ratio in the two patient groups was significantly higher than that in controls (P<0. 05 in cirrhosis i P<0. 001 in hepatic caner) and there is also significant difference between the two patient groups (P<0. 001). Conclusion: the measurement of serum copper and copper/zinc ratio is helpful for differential diagnosis between cirrhotic and hepatic cancer patients.
关键词
铜
锌
肝肿瘤
鉴别诊断
Cirrhosis Hepatic cancer Serum copper Copper/zinc ratio
