白塞病的临床特征中医辩证及细胞免疫功能的变化

A study of clinical features, differential Diagnosis in TCM and Identification of T subsets in Peripheral in BD patients

作者对30例白塞病(BD)临床特征观察表明:30例患者中完全型7例,不完全型23例.在BD出现的各种损害中,以反复发作的口腔溃疡为最常见及早期征象,且病程较长,平均7.5年,其次为生殖器溃疡.同时根据30例患者临床症候及舌苔脉象改变进行中医辩证,将其分为湿热毒结型9例,肝肾阴虚型15例,脾肾阳虚型6例,并在此基础上论述了三种中医分型的临床意义,用以探讨本病辩证论治分型的规律.此外,对30例患者外周细胞免疫功能检测结果发现:BD患者外周血CD_4、CD_8细胞数目低于正常对照组,IL-2活性降低,P<0.05.提示BD患者外周血细胞免疫功能存有缺陷.

The Clinical features of 30 patients with BD were observed. 7 were complete type, the others wereimcomplete. Among various clinical appearance in BD, the most common sign is recurrent oral ulcer lupto 100%, and the second is genital ulcer, meanwhile, we classified these patients into three types -Ⅰ: toxic syndrone produced by wetness -heat evil (9 cases )s Ⅱ : deficiency of liver -yin and kindey - yin(15 cases); Ⅲ;deficiency of spleen -yang and kindney-yang (6 cases), according to the clinical signs and the changes of coating of tongne or pulse condition in TCM and we discussed the importance and regularity of this differential classfication. In addition, we detected the cell immune function of peripheral blood in BD patients, the results indicated that the level of CD4,CD8 were lower and Ⅱ-2 activity was decreased in BD group, when compared with controls this suggested that there was some defected in the cell immune function of peripheral blood with BD patients.