槲皮素对糖尿病大鼠周围神经病变的保护作用

Protective effect of quercetin on pathological change in peripheral nerve in diabetic rats

槲皮素对糖尿病大鼠周围神经病变的保护作用１王新嘉何国芬２克明３李贵民３张辉（山西医科大学第二附属医院内科，太原０３０００１）周围神经组织的非酶糖基化与糖尿病神经病变的发生有关［１］，最近发现抗氧化剂槲皮素（ｑｕｅｒｃｅｔｉｎ）对组织蛋白非酶糖基化有...

In order to study the protective role of quercetin on diabetic neuropathy in streptozotocin induced diabetic rats, the motor nerve conduction velocity (MNCV) and the content of advanced glycosylation end products (AGEP) in sciatic nerve were examined, in comparing with the effect of aminoguanidine (50 mg·kg 1 ·d 1 for 16 wk, ig). Quercetin (100 mg·kg 1 ·d 1 for 16 wk, ig) treatment significantly lowered the content of AGEP and improved the MNCV in the sciatic nerve. These findings suggest that quercetin may have a similar protective role in diabetic neuropathy as aminoguanidine.