超氧化物歧化酶脂质体的药物代谢动力学及抗炎作用

Pharmacokinetics and anti inflammatory effect of liposome entrapped superoxide dismutase

超氧化物歧化酶脂质体的药物代谢动力学及抗炎作用童荣生１叶松柏陆彬２（华西医科大学药理学教研室，２药剂学教研室，成都６１００４１）超氧化物歧化酶（ｓｕｐｅｒｏｘｉｄｅｄｉｓｍｕｔａｓｅ，ＳＯＤ）作为超氧阴离子（Ｏ－２）的特异性清除剂，在动物实验和临床上...

The liposome entrapped superoxide dismutase (L SOD) was prepared with the optimum experimental conditions. The pharmacokinetics, distribution in tissues and anti inflammatory effects on animals of SOD and L SOD have been investigated comparatively. The results showed that the pharmacokinetics properties were greatly improved when SOD was entrapped by liposomes, with t 1/2β prolonged from 40±10 min to 225±32 min, the clearance reduced and AUC increased markedly in rabbits. The L SOD showed the higher concentration in the main tissues except kidney, reached its maximal concentration more rapidly and stayed longer in all tissues than SOD following ip in mice. The L SOD had a more stronger and longer suppressing effect on the swelling of foot induced by carrageenan in mice and rats.