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Toll样受体与类风湿关节炎 被引量:2

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摘要 Toll样受体(toll like receptor,TLR)是一类重要模式识别受体(pattern recognition receptor,PRR),参与识别多种非特异性的、保守的微生物组分以及相应内源性配体。它们不仅在天然免疫中具有重要作用.也是联系天然免疫与特异性免疫的桥梁,从多个方面影响特异性免疫应答,因此在包括类风湿关节炎(rheumatoid arthritis,RA)在内的慢性免疫性炎症疾病的发生发展中扮演着重要角色。本文将综述近年来TLR最新的研究进展,并探讨其与RA的关系。
出处 《中华风湿病学杂志》 CAS CSCD 2008年第1期45-48,共4页 Chinese Journal of Rheumatology
基金 国家自然科学基金资助项目(30571725) 教育部留学回国启动基金资助项目([2005]546)
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参考文献25

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二级参考文献24

  • 1潘正论,张源潮,许冬梅,马春燕.天然免疫分子TLR2 TLR4在类风湿关节炎的表达模式研究[J].中华风湿病学杂志,2005,9(2):86-88. 被引量:5
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