血管瘤样纤维组织细胞瘤

A case of angiomatoid fibrous histiocytoma

报告1例血管瘤样纤维组织细胞瘤。患者女,24岁。因左胫前出现无痛性紫红色皮下结节4年就诊。皮损组织病理检查:真皮下层可见肿瘤细胞团块,肿瘤主要由成纤维细胞样细胞和组织细胞样细胞组成,在肿瘤团块中可见数处不规则出血性裂隙和囊腔,但管周无内皮细胞。免疫组化染色示肿瘤细胞波形蛋白(vimentin)、平滑肌肌动蛋白(SMA)、上皮膜蛋白(EMA)和CD68阳性,而结蛋白(desmin)、S-100蛋白、CD31、CD34和Ⅷ因子相关抗原均阴性。结合临床表现、组织病理改变和免疫组化染色,诊断为血管瘤样纤维组织细胞瘤。

A case of angiomatoid fibrous histiocyloma is reported. A 24-year-old woman presented wilh a red-violet, painless. firm subcutancous nodule on her left leg for 4 years. Histopathological examination showed masses of lumor cells consisting of fibroblast- and histiocyte-like cells eontaining haemosiderin, and there were multifocal areas of irregular haelnorrhagic fissures and cavities in the masses without endothelial lining. In addition, lymphocytes and plasma cells were evident around the periphery of the tumor, Immunohistochemical analysis showed that the tumor cells stained positive whh vimentin, SMA. E MA and CD68. but not for desmin, S-100, CD31, CD34 and factor Ⅷ-related antigen. These findings were consistent with angiomatoid fibrous histiocytoma.