干扰素联合窄谱中波紫外线治疗皮肤T细胞淋巴瘤16例

Interferon-α combined with narrowband UVB phototherapy in the treatment of patients with cutaneous T-cell lymphomas

目的:观察干扰素(IFN)-α联合窄谱中波紫外线(NB-UVB)治疗皮肤T细胞淋巴瘤的临床疗效。方法:对16例皮肤T细胞淋巴瘤患者采用重组人IFN-α联合NB-UVB治疗。结果:治疗后16例患者完全缓解率为37.5%,有效率为87.5%,无明显不良反应。结论:IFN-α联合NB-UVB治疗皮肤T细胞淋巴瘤是一种安全有效的方法。

Objective： To evaluate the efficacy of interferon-or combined with narrowband UVB phototherapy in the treatment of patients with cutaneous T-cell lymphomas （CTCL）. Methods： Sixteen patients with CTCL were treated by interferon-or combined with narrowband UVB. Results： The rate of complete remission was 37.5%, with overall response rate 87.5%. No adverse side effects were observed. Conclusion： Interferon-or combined with narrowband UVB in the treatment of patients with cutaneous T-cell lymphomas （CTCL） is an effective and safe therapy.