赤魟尾刺提取物的抗肿瘤作用

Antitumor Effects of the Extracts from Caudal Spine of Dasyatis akajei

赤缸Dasyatis akajei（Muller＆henle）隶属于软骨鱼纲，下孔总目，鲼形目，魟科，魟属，常栖息于底质为泥沙的深潭中。赤魟肉性昧甘、咸平，有补气之功效。用其熬油，主治小儿疳积。尾刺研末入药，对治疗胃癌、食道癌、肺癌、乳腺炎、咽喉炎、疟疾、牙痛、魟鱼尾刺刺伤均有一定疗效。赤魟尾刺含有多种毒素，有重要药理作用。涂洪斌等克隆出编码赤魟肿瘤抑制因子IPL的全长cDNA序列，并报道了赤魟亲环素A的融合表达、纯化及活性特征。

In vivo antitumor effects of the extracts from caudal spine of Dasyatis akajei by 20% alcoholic and 1% hydrochloride were investigated by testing the tumor weight of tumor-beating mice （S180）. The results showed that the extracts of caudal spine of Dasyatis akajei exhibited obvious inhibitory effects on the growth of S180.