5Morishita M, Morishita I, Takayamak, et al. Novel oral micro - sphere of insulin with protease inhibitor pretecting enzymatic degradation [ J ]. International Journal of Pharmaceutics,1992,78( 1 ) : 17.
7Agarwal Vikas, Reddy IK, Khan MA. Polymethyacrylate based microparticulates of insulin for oral delivery : Preparation and in vitro dissolution stability in the presence of enzymeinhibitors [ J ]. International Journal of Pharmaceutics,2001,225 :31.
7[1]Muramatsu K, Maitani Y, Nagai T. Dipalmitoylphosphatidylcholine liposomes with soybean-derived sterols and cholesterol as a carrier for the oral administration of insulin in rats [J]. Biol Pharm Bull, 1996, 19(8):1055-1058.
8[2]Choudhari KB, Labhasetwar V, Dorle AK. Liposomes as a carrier for oral administration of insulin: effect of formultion factors [J]. J Microencapsulation, 1994, 11(3):319-325.
9[3]Aspden TJ, Mason JDT, Jones NS, et al. Chitosan as a nasal delivery system: The effect of chitosan solutions on in vitro and in vivo mucocilliary transport rates in human turbinates and volunteers [J]. J Pharm Sci, 1997, 86(4):509-513.
10[4]Henriksen I, Vagen SR, Sande SA, et al. Interaction brtween liposomes and chitosan II: effect of selected parameters on aggregation and leakage [J]. Int J PHarm, 1997, 146:193-204.
5Muramausu K,Maitani Y,Takayama K,et al.The relationship between the rigidity of the liposomal membrane and the absorption of insulin after nasal administration of liposomes modified with an enhancer containing insulin in rabbits[J].Drug Dev Ind Pharm,1999,25(10):1099.
6Iwanaga K,Ono S,Narioka K,et al.Application of surface coated liposomes for oral delivery of peptide:effects of coating the liposomes surface on the GI transit of insulin[J].J Pharm Sci,1999,88(2):248-252.
7Harsch IA.Inhaled insulins:their potential in the treatment of diabetesmellitus[J].Treat Endocrinol,2005,4(3):131-138.
8Patton JS,Bukar JG,Eldon MA.Clinical pharmacokinetics and pharmacodynamics of inhaled insulin[J].Clin Pharmacokinct,2004,43(12):781-801.
9Usman IOS,Biddiscombe MF,Barmes PJ,Regional lung deposition and bronchodilator response as a function of beta-agonist particle size[J].Am J Respir Crit Care Med,2005,172(12):1497-1504.
10Mcgurk JG,Ross AR,Gilroy GC.A novel method for the in-situ preparation of liposomes using an aerosol delivery system[J].J Pharm Pharmacol,1986,38:20.
