青少年多囊卵巢综合征与其父母代谢综合征的相关性研究

Study to the relationship of adolescent polycystic ovary syndrome with parental metabolic syndrome

目的探讨青少年多囊卵巢综合征（PCOS）与其父母代谢综合征（MBS）的相关性。方法选择2004年3月—2007年3月在浙江省慈溪市妇幼保健院与慈溪市人民医院的36例PCOS青少年患者（11～16岁）及其父母（35例母亲,19例父亲）、21例正常青少年（女,11～16岁）,进行其体质量指数（BMI）、腰围、血压测量,并检测其血清胆固醇（TC）、三酰甘油（TG）、雄性激素水平,同时进行糖耐量测定（OGTT）及超声检查多囊卵巢情况。结果①PCOS患者的父亲94%肥胖或超重,79%患有MBS。②PCOS患者的母亲停经前36%患MBS,明显高于患PCOS者（≤20%）。③PCOS患者的多囊卵巢特征极少数遗传于母亲,其主要遗传于父亲的MBS因素（P=0.008）。④PCOS患者中28%患有MBS。结论青少年PCOS在根本上是由其父亲患有MBS遗传因素所致。

Objective It is to approach the relationship of adolescent polycystic ovary syndrome（PCOS） phenotype with parental polycystic ovary syndrome（MBS）.Methods 16 girls with PCOS（11 to 16 years old） and their parents（35 mothers and 19 fathers） both in the Maternity and Child Health Hospital of Cixi City and the People′s Hospital of Cixi City from March 2004 to March 2007 by choice,the body mass index（BMI）,waistline,blood pressure of them were measured,and the levels of TC,TG,Testosterone of them were detected,as well as oral glucose tolerance test and polycystic ovary status detection by ultrasonic scanner were executed.And 21 healthy girls（11 to 16 years old） as reference were detected.Results ①94% fathers of girls with PCOS were obesity or overweight,and 79% were MBS.②36% premenopausal mothers of girls with PCOS were MBS,while only less than 22% were PCOS.③The polycystic ovary status in girls with PCOS were less heredity from their mothers,but capital heredity from their fathers′ MBS（P=0.008）.④27.8% girls with PCOS were MBS.Conclusion Paternal MBS is the fundamental factor of their children′s PCOS.