摘要
目的研究灯盏乙素对DPPH所致血管内皮依赖性舒张功能障碍的影响.方法采用家兔胸主动脉血管环DPPH氧化损伤模型评价灯盏乙素对内皮依赖性舒张反应的影响.结果灯盏乙素能显著减轻DPPH对乙酰胆碱(Ach)诱导的血管内皮依赖性舒张反应的抑制作用.结论灯盏乙素对血管内皮依赖性舒张功能具有保护作用.
Objective To study the effects of scutellarin on endothelium-dependent relaxation dysfunction of rabbit thoracic aorta caused by DPPH. Methods Model of oxidative damage on rabbit vascular ring of thoracic aorta was used to evaluate effects of scutellarin on vascular endothelium-dependent relaxation response. Results Scutellarin obviously depressed the DPPH＇s inhibition on vascular endothelium-dependent relaxation response induced by acetylcholine （Ach）, Conclusion Scutellarin has evident protective effects on vascular endothelium-dependent relaxation response.
出处
《昆明医学院学报》
2007年第6期6-9,共4页
Journal of Kunming Medical College
基金
云南省自然科学基金资助项目(2004C0019Q)
云南省医药与生物技术创新人才联合培养基地基金
昆明医学院创新群体基金(KMC2005DG04)
关键词
灯盏乙素
DPPH
胸主动脉环
内皮依赖性舒张反应
Seutellarin
DPPH
Vascular ring of thoracic aorta
Endothelium-dependent relaxation response
