曲安奈德对家免视网膜的病理组织学的影响

Retinal Changes of Intravitreal Triamcinolone Acetonide: a Pathohistological Study

目的比较研究进口及国产不同剂量曲安奈德(TA)玻璃体内注射对家兔视网膜组织形态学的影响.方法家兔24只,分为6组:A组;B组;C组;D组;E组和F组.除A组外所有动物行右眼玻璃体切除术后注射曲安奈德(IVTA)1次,给药后观察21d,取眼球,行病理学检查.结果除A组外,其它各组可见节细胞轻度水肿.E组和F组部分动物见内或外颗粒层细胞增生,细胞内空泡.E组和F组各有1只动物见玻璃体腔内、视网膜与脉络膜之间大量红染纤维素样物质.E组和F组病变重于C组和D组.结论IVTA 25mg引起家兔眼感光细胞增生,IVTA10 mg无明显改变.进口与国产的TA对家兔视网膜的影响无明显差别.

Objective To investigate the effect of triamcinolone acetonide （TA） with different dosage and place of production on retina. MethOdS Twenty-four rabbits were divided into 6 groups （A： untreated as a blank control; B： normal sodium; C： 10mg imported TA; D： 10 mg domestic-made TA; E： 25 mg imported TA; F： 25 mg domestic-made TA） , Excepting group A every fight eyeball underwent vitrectomy before intravitreal injection triamcinolone acetonide, All the eyeballs were extirpated on the 21st day after the intravitreal injection, and then pathological examinations were performed. Results Ganglion cell＇ s light edemata had been seen in group B, C, D, E, F. Cell hyperplasia and vacuolar degeneration had been seen in the internal granular layer or external granular layer in some animals of group E, F. Two samples （1 in group E, 1 in group F） observed there were a great amount of fibrinoid materials in cavum vitreum and cavum between amphiblestroid membrane and choroid membrane. Pathological changes in group E, F were severer than in group C, D. Conclusions Intravitreous injection TA at 25 mg can cause photoreceptor cells hyporplasia in rabbits, while there are no toxic effects at 10 mg. No obvious difference is observed between the groups of imported TA and domestic-made TA.