冠心病患者肱—踝脉搏波速与血管内皮舒张功能相关

The Relationship Between Brachial-Ankle Pulse Wave Velocity and Flow-Mediated Vasodilation in Patients with Coronary Heart Disease

目的探讨冠心病患者肱—踝脉搏波速与内皮依赖性舒张功能的关系。方法选择98例冠心病患者和33例非冠心病对照者,采用高分辨率超声检测肱动脉血流介导的内皮依赖性血管舒张功能;自动脉搏波速度测定仪测定肱—踝脉搏波速。结果冠心病组肱动脉血流介导的内皮依赖性血管舒张功能明显低于对照组(5.4%±2.5%比11.1%±4.4%,P<0.01),冠心病组肱—踝脉搏波速明显高于对照组(1745.3±215.2cm/s比1495.3±202.3cm/s,P<0.01),两组硝酸甘油介导的内皮非依赖性血管舒张功能无明显差异;肱动脉血流介导的内皮依赖性血管舒张功能与肱—踝脉搏波速呈负相关(r=-0.70,P<0.001)。结论冠心病患者血管内皮功能受损和肱—踝脉搏波速增快,提示血管内皮舒张功能的受损伴随冠心病动脉硬化。

Aim To explore the relationship between brachial-ankh pulse wave （baPWV） and flow-mediated vasodilation （FMD） in patients with coronary heart disease （CHD）. Methods 98 patients with CHD and 33 control subjects were recruited in the study, baPWV velocity was measured non-invasively using VP 1000 automated ABI/PWV analyzer. Flow-mediated vasedilation （FMD） in the brachial artery was measured by high-resolution ultrasound, Results FMD was significantly reduced in CHD patients compared with that in control subjects （5.4% ± 2.5% vs 11.1 ±4.4%, P 〈0.01 ） ; and baPWV was increased in CHD group as compared to the control group（1745.3±215.2cm/s vs 1495.3±202.3cm/s, P〈0.01）, There was a significant correlation between baPWV and FMD in patients with CHD （r= -0.70, P〈0.001）. Conclusions There were increased baPWV and impaired endothelial function in patients with CHD. The correlation between flow-mediated vasodilation and brachial-ankh pulse wave velocity was high.