肝纤维化的临床研究进展

Advances in Clinical Research of Hepatic Fibrosis

肝纤维化是所有慢性肝病的共同特征,多种因素参与其发生和发展。各种因素所致的肝纤维化的进程不同,但目前对其自然史的认识尚不全面。肝纤维化的非创伤性诊断临床实际应用尚有一定距离,对临床、生化和影像等指标进行综合评估应是今后努力的方向。肝纤维化和肝硬化可出现逆转和消失完全改变了对其治疗的认识。目前尚无有效的肝纤维化治疗药物,最有效的治疗方法仍是病因治疗。肝纤维化药物治疗开发存在不少困难,但前景广阔。

Hepatic fibrosis is the common characteristic of chronic liver diseases with various etiologies, and many factors are involved in its development. The courses of hepatic fibrosis caused by various factors are different, and the recognition of its natural history is not yet well known. The actual application of noninvasive methods for the diagnosis of hepatic fibrosis has some gaps, and comprehensive evaluation of clinical, biochemical and imaging markers of hepatic fibrosis should be the goal for further studies in the future. Reversion and disappearance of hepatic fibrosis and cirrhosis may change the recognition of treatment. At present, there is no effective drug for hepatic fibrosis, and therapy on the etiologies is still the most effective measure. Although there are many difficulties in the development of drug therapy for hepatic fibrosis currently, yet its prospect is promising.