摘要
Sugammadex是一新型的肌松药拮抗药,它可以和神经肌肉阻滞药结合,阻止其在神经肌肉接头处发挥作用。目前该药已经进入Ⅲ期临床研究。研究表明sugammadex能够安全、有效地迅速拮抗非去极化肌松药的深度神经肌肉阻滞作用。因其起效快且无明显不良反应,该药可能改变目前麻醉中应用肌松药的方法。现就有关该药的临床研究进展和sugammadex可能带来的潜在变革作一综述。
Sugammadex is a novel drug that binds neuromuscular blocking drugs and prevents them from acting at the neuromu cular junction. Currently,the drug is undergoing phase Ⅲ clinical trials, Sugammadex has been shown to be safe and efficacious in rapidly reversing profound nondepolarizing neuromuscular block. Due to its rapid onset and relative lack of side effects, this drug promises to change the method of using muscle relaxants during anesthesia. This review summarizes the current clinical studies on the drug and addresses some of the potential changes that it may bring.
出处
《国际麻醉学与复苏杂志》
CAS
2007年第6期548-551,共4页
International Journal of Anesthesiology and Resuscitation
关键词
罗库溴铵
肌松药拮抗药
环糊精
逆转
rocuronium
muscle relaxant antagonist
cyclodextrin
reversal
