尼莫地平纳米脂质微粒大鼠体内药动学及生物利用度研究

Study on Pharmacokinetics and Bioavailability of Nimodipine Nanostructured Lipid Carrier in Rats

目的考察尼莫地平纳米脂质微粒的大鼠体内药动学性质与生物利用度。方法建立反相高效液相色谱法测定尼莫地平血药浓度的方法,考察纳米脂质微粒载体对SD大鼠口服尼莫地平药动学参数及生物利用度的影响。结果经液态脂质修饰的尼莫地平纳米脂质微粒,其达峰时间较尼莫地平片剂延长2.3 h,生物利用度为尼莫地平片剂的3.26倍。结论尼莫地平纳米脂质微粒能显著提高尼莫地平的口服生物利用度。

OBJECTIVE To evaluate the pharmacokinetics and bioavailability of nimodipine nanostructured lipid carrier in rats.METHODS A RP-HPLC method was established to determine the concentration of nimodipine in plasma.Nimodipine loaded nanostructured lipid carrier（NLC） were prepared by solvent dispersion method,and its pharmacokinetic parameters and bioavailability in SD rats were studied after administration.RESULTS Compared with nimodipine tablet,the tmax of nimodipine loaded NLC was delayed by 2.3 h,and the bioavailability of nimodipine NLC was increased by 2.26 folds.CONCLUSION Nimodipine loaded NLC obviously enhanced the bioavailability of nimodipine in rats after oral administration.