硫普罗宁治疗慢性病毒性肝炎的临床疗效对照研究

Clinical efficacy of tiopronin on chronic viral hepatitis

目的:评价硫普罗宁治疗慢性病毒性肝炎的临床疗效。方法:将108例慢性病毒性肝炎患者随机分为A,B,C 3组,每组36例。分别接受4周的硫普罗宁针、还原型谷胱甘肽针、基础护肝(葡醛酸钠、肌苷)针治疗,检测患者治疗前后肝功能,临床症状和体征的改善情况。结果:A组改善肝功能及临床症状的总有效率(86.1%)明显优于B组(75.0%,P<0.01)和C组三组(61.1%,P<0.01)。A与B组肝功能ALT和ALB的改善差异无显著性(P>0.05),但对降低AST及TB IL方面A组优于B组(P<0.05)。结论:硫普罗宁能有效地改善肝功能及临床症状。

Objective：To evaluate the therapeutic effect of tiopronion on chronic viral hepatitis. Methods：Totally 108 patients with chronic viral hepatitis were randomly divided into three groups （n =36 for each group） , and treated for 4 weeks with tiopronion, reduced gluthion and basic drugs （including glucurone and inosine） , respectively. Liver function, clinical sings and determined in all the patients at the onset and end of the treatments. Results：The overall tiopronion （86.1% ） to improve liver function and clinical symptom was markedly higher liver-protecting symptoms were effective rate of than that of re-duced gluthion （75.0% , P 〈0.01） or basic drugs （61.1% , P 〈0.01）. The effect of tiopronion was similar to that of reduced gluthion on decreasing ALT and ALB （P 〉 0.05 ） , but was superior to that of reduced gluthion on decreasing AST and TBIL （P 〈 0.05 ）. Conclusion ： Tiopronion can effectively improve hepatic function and clinical signs of patients with chronic viral hepatitis.