摘要
为了探讨苏丹红Ⅱ对小鼠血液的影响,研究了不同剂量苏丹红II对小鼠的红细胞、白细胞、血红蛋白的毒性作用以及对凝血时间的影响。采用了腹腔注射(i.p)的方法染毒,每天注射1次,每次注射0.2ml,对照组注射溶剂0.2ml,连续注射15天,于染毒20d取小鼠血液,对小鼠红细胞、白细胞及血红蛋白进行计数,并测定凝血时间。对实验结果进行了t检验和相关性分析。结果表明:1)苏丹红Ⅱ可引起小鼠红细胞、血红蛋白数量的减少,且呈剂量-效应关系。2)苏丹红Ⅱ可使小鼠白细胞数、凝血时间随染毒剂量的增加而增加。由此推论,1)苏丹红Ⅱ对血小板可能有破坏作用,进而表现为凝血时间延长。2)苏丹红Ⅱ对小鼠红细胞、白细胞及血红蛋白有毒性作用。
To investigate the influence the SudanⅡ takes on the blood of the mouse, study the variety of the red cell, immune cell, Hb the clotting time. SudanⅡ caused Mice were continually injected SudanⅡ once a day for 15 days. Mice were killed on 20 days after the first injection, then the quantity of the four components in the blood were recorded and analyzed. 1）the SudanⅡ caused the decrease in the red cell and Hb quantity. 2）an increase in the immune cell quantity and clotting time. 1） the SudanⅡ may inhibit and spoil the form of thing causes the blood to clot quickly, so,it let the clotting time increase. 2） the SudanⅡ has toxicity effect on the blood cell.
出处
《齐齐哈尔医学院学报》
2007年第20期2433-2435,共3页
Journal of Qiqihar Medical University
