期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

转基因家兔模型在生物医学研究中的应用现状与进展 被引量：2

下载PDF
导出
摘要 转基因家兔是生物医学研究重要的实验动物模型,表达人类基因的转基因家兔已经被广泛应用在人类心血管病、艾滋病、癌症等疾病的研究中,特别是利用转基因家兔模型在人类动脉粥样硬化实验研究中已经取得了令人注目的成绩。本文对转基因家兔模型制作及其在生物医学研究中的应用现状、进展和发展趋势进行了综述。
作者 贾锐胜 张光伟
机构地区 陕西省西安市迪乐普生物资源开发有限公司 西安交通大学医学院实验动物中心西安医学院基础医学部
出处 《齐齐哈尔医学院学报》 2007年第20期2481-2484,共4页 Journal of Qiqihar Medical University
关键词 转基因 家兔 生物医学 动物模型
分类号 R646 [医药卫生—外科学]
  • 相关文献

参考文献19

  • 1刘恩岐,范江霖.转基因兔在动脉粥样硬化研究中的应用及其进展[J].中国动脉硬化杂志,2003,11(4):371-375. 被引量：23
  • 2Fan J,Watanabe T.Transgenic rabbits as therapeutic protein bioreactors and human disease models[J].Pharmacol Ther,2003,99(3):261-282.
  • 3Hammer RE,Pursel VG,Rexroad Jr,et al.Production of transgenic rabbits,sheep and pigs by microinjection[J].Nature,1985,315 (6021):680-683.
  • 4刘恩岐,郑华东,赵四海,杨鹏辉.转基因家兔模型制作方法[J].动物学杂志,2006,41(3):62-69. 被引量：12
  • 5Chesne P,Adenot P G,Viglietta C,et al.Cloned rabbits produced by nuclear transfer from adult somatic cells[J].Nat Biotechnol,2002,20(4):366-369.
  • 6Fan J,Wang J,Bensadoun A,et al.Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins[J].Proc Natl Acad Sci USA,1994,91(18):8 724-8 728.
  • 7Rouy D,Duverger N,Lin SD,et al.Apolipoprotein(a) yeast artificial chromosome transgenic rabbits.Lipoprotein(a) assembly with human and rabbit apolipoprotein B[J].J Biol Chem,1998,273(2):1 247-1 251.
  • 8Duverger N,Viglietta C,Berthou L,et al.Transgenic rabbits expressing human apolipoprotein A-I in the liver[J].Arterioscler Thromb Vasc Biol,1996,16(12):1 424-1 429.
  • 9Huang Y,Schwendner SW,Rall SC Jr,et al.Apolipoprotein E2 transgenic rabbits.Modulation of teh type Ⅲ hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis[J].J Biol Chem,1997,272(36):22 685-22 694.
  • 10Hoeg JM,Vaisman BL,Demosky SJ Jr,et al.Lecithin:cholesterol acyltransferase overexpression generates hyperalpha-lipoproteinemia and a nonatherogenic lipoprotein pattern in transgenic rabbits[J].J Biol Chem,1996,271(8):4 396-4 402.

二级参考文献44

  • 1刘恩岐,Shuji Kitajima,Masatoshi Morimoto.CREATE TRANSGENIC RABBITS BY MICROINJECTING HUMAN apoA-Ⅱ GENE INTO FERTILIZED EGGS[J].Journal of Pharmaceutical Analysis,2004,16(1):67-70. 被引量：7
  • 2Fan J,Shimoyamada H, Sun H, et al.Transgenic rabbits expressing human apolipoprotein(a) develop more extensive atherosclerotic lesions in response to a cholesterol-rich diet.Arterioscler Thromb vasc Biol,2001,21:88-94
  • 3Ichikawa T, Unoki H, Sun H, et al.Lipoprotein (a) promotes smooth muscle cell proliferation and dedifferentation in atherosclerotic lesions of human apo(a)transgenic rabbits.Am J Pathol,2002,160:227-236
  • 4Huang Y,Schwendner SW, Rall SC, et al.Apolipoproein E2 transgenic rabbits: modulation of the type Ⅲ hyperlipoproteinemic phenotype by estrogen and occunence of spontaneous atherosclerosis.J Biol Chem,1997,272:22 685-694
  • 5Fan J,Zhong-Sheng J, Huang Y, et al.Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma.J Clin Invest,1998,101:2 151-164
  • 6Huang Y, Ji ZS, Brecht WJ, et al.Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis.Arterascler Thromb Vasc Biol,1999,19:2 952-959
  • 7Yamanaka S,Balestra ME,Ferrell LD,et al.Apoplipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.Proc Natl Acad Sci USA,1995,92:8 483-487
  • 8Qian X, Balestra ME,Yamanaka S,et al.Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors.Arteriascler Thromb Vasc Biol,1998,18:1 013-020
  • 9Fan J, Wang J, Ji ZS,et al.Transgenic rabbits overexpreasion human hepatic lipase have reduced level of high density lipoproteins and intermediate density lipoproteins and diminished response to dietary cholesterol.Circulartion,1994,90(Suppl 1):298
  • 10Fan J,Wang J,Ji ZS,et al.Transgenic rabbits overexpression human hepatic lipase have reduced level of high density lipoproteins and intermediate density lipoproteins and diminished response to dietary cholesterol.Circulation,1994,90(Suppl I):298

共引文献27

同被引文献39

引证文献2

二级引证文献2

齐齐哈尔医学院学报
2007年 第20期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部