小鼠骨髓微核试验评价某市水源水及自来水的遗传毒性

Evaluation of Genotoxicity of Source Water and Tap Water Samples by Using Mouse Micronucleus Test

在以往Ames和VDS试验的基础上,运用小鼠体内微核试验检测了某市自来水公司所属的8个水厂水源水、自来水及2个新拟建水厂源水的有机提取物的遗传毒性。结果表明,除2个新拟建水厂的源水外,该市原来的水源水和自来水、均可不同程度地诱导小鼠微核率的升高,并有明显的剂量反应关系。这说明,该市原来的水源水已受到不同程度的污染,而2个新拟建水厂的取水点则水质较好。

On the bases of Ames test and VDS test, using mouse micronucleus test to determine the genotoxi-city of the source water, tap water samples of eight waterworks and the organic extraction from two proposed waterworks of certain city. The result showed that besides the source water from two proposed waterworks, the source water, tap water could induce increasing micronucleus frequency and show obvious dose response relation. It may be demonstrated that the source water of this city has been polluted of certain degree, and the water qualities of the two proposed waterworks are rather good.