曲美他嗪对扩张型心肌病心力衰竭患者心功能的疗效观察

Therapeutic value of trimetazidine on patients with dilated cardiomyopathy and congestive heart failure

目的观察曲美他嗪(TMZ)对扩张型心肌病(DCM)患者心力衰竭的临床疗效。方法46例DCM伴中重度心力衰竭患者随机分为TMZ治疗组(TMZ组)和常规治疗组(对照组)。对照组予常规抗心力衰竭治疗,TMZ组在常规治疗的基础上加用TMZ20mg,3次/d,观察治疗前和治疗20周后患者心功能分级、左室射血分数(LVEF)、左室收缩末期内径(LVEDs)、左室舒张末期内径(LVEDd)的变化。结果治疗20周后,TMZ组心功能分级的显效率和总有效率均显著优于对照组(P<0.05),超声心动图LVEF明显提高(P<0.01),LVEDs和LVEDd显著缩小(P<0.05,P<0.01)。结论曲美他嗪可以改善DCM患者的心功能,可以作为辅助治疗。

Objective To study the clinical therapeutic effect of trimetazidine （TMZ） on Dilated Cardiomyopathy （DCM） accompanied by moderate to sever congestive heart failure.Methods 46 patients with DCM accompanied by moderate to sever congestive heart failure were randomized into routine treated group and TMZ treated group （TMZ group）, and the patients in TMZ group received TMZ （20 mg 3 times per day） for twenty weeks. All their grades of heart function, left ventricular ejection fraction（LVEF）, left ventricular end-systolic diameter （LVEDs）, left ventricular end-diastolic diameter （LVEDd） before and after treatment with TMZ was ob- served. Results The heart function grade of patients there were greatly improved in TMZ group （P〈0.05）,LVEF was obviously increased（P〈0.01 ）, the LVEDs and LVEDd were greatly reduced（P〈0.05, P〈0.01 ）. Conclusion TMZ seems to improve the heart function of patients with DCM, and this method is worth being utilized.